Results
| PMID | 17086305 |
| Gene Name | MUC16 |
| Condition | Endometriosis (Pelvic) |
| Association |
Associated |
| Population size | 52 |
| Population details | 52 (35 patients with biopsy-confirmed pelvic endometriosis, 17 patients without endometriosis) |
| Sex | Female |
| Associated genes | CA-125 |
| Other associated phenotypes |
Pelvic endometriosis |
|
Sao Paulo Med J. 2006 Jul 6;124(4):223-7. Amaral, Vivian Ferreira do| Ferriani, Rui Alberto| Sa, Marcos Felipe Silva de| Nogueira, Antonio Alberto| Rosa e Silva, Julio Cesar| Rosa e Silva, Ana Carolina Japur de Sa| Moura, Marcos Dias de Gynecology and Obstetrics Department, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil. CONTEXT AND OBJECTIVE: One of the diagnostic markers of endometriosis is CA-125, and elevated levels of this are caused by high concentrations in the ectopic endometrium. The objective of this study was to correlate CA-125 levels in serum and peritoneal fluid from women with and without pelvic endometriosis. DESIGN AND SETTING: This was a prospective, cross-sectional, controlled study of consecutive patients undergoing laparoscopy for infertility, pelvic pain or tubal ligation, during early follicular phase, at the university hospital of Faculdade de Medicina de Ribeirao Preto. METHODS: Fifty-two patients were divided into two groups: endometriosis group, consisting of 35 patients with biopsy-confirmed pelvic endometriosis, and control group, consisting of 17 patients without endometriosis. CA-125 levels in serum samples and peritoneal fluid were determined by chemiluminescence. RESULTS: CA-125 levels in serum and peritoneal fluid were higher in patients with advanced pelvic endometriosis (means of 39.1 +/- 45.8 U/ml versus 10.5 +/- 5.9 U/ml in serum, p < 0.005; 1,469.4 +/- 1,350.4 U/ml versus 888.7 +/- 784.3 U/ml in peritoneal fluid, p < 0.05), and showed a positive correlation between each other (correlation coefficient (r) = 0.4880). Women with more advanced degrees of endometriosis showed higher CA-125 levels in both serum and peritoneal fluid (p = 0.0001). CONCLUSION: There is a positive correlation between serum and peritoneal fluid values of CA-125 in women with and without endometriosis, and their levels are higher in peritoneal fluid. Advanced endometriosis is related to higher levels in both serum and peritoneal fluid. Mesh Terms: Adult| Ascitic Fluid/*chemistry/metabolism| Biomarkers/analysis/blood| CA-125 Antigen/*blood| Endometriosis/blood/*metabolism| Epidemiologic Methods| Female| Humans| Laparoscopy| Menstrual Cycle/metabolism|DA 2007/06/05 09:00 |
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